Monte Carlo Simulation of Kinesin Movement with a Lattice Model

Kinesin 是由拿大约 8 nm 沿着一根微导管移动的分子的马达走的 processive 双 headed。它通常水解为采取每项前面的措施的一个 ATP 分子。kinesin 的 processive 运动分子的马达数字地与一个晶格模型被模仿。当 Brownian 粒子和两个头的 ATPase 过程被考虑，马达被考虑。蒙特卡罗模拟结果与最近的试验性的观察同意很好，特别在速度对 ATP 和自动数据处理集中的关系上。

Kinesin is a processive double-headed molecular motor that moves along a microtubule by taking about 8nm steps. It generally hydrolyzes one ATP molecule for taking each forward step. The processive movement of the kinesin molecular motors is numerically simulated with a lattice model. The motors are considered as Brownian particles and the ATPase processes of both heads are taken into account. The Monte Carlo simulation results agree well with recent experimental observations, especially on the relation of velocity versus ATP and ADP concentrations.