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抑郁症的分子遗传学研究进展 被引量：1

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摘要 抑郁症是复杂性疾病,其分子遗传学研究方法不同于单基因遗传病。本文综述了抑郁症基因定位和候选基因两种分子遗传学研究方法和进展。
作者 钱烈 李惠春
机构地区 浙江大学附属第二医院精神科
出处 《国际精神病学杂志》 2005年第3期140-143,共4页 Journal Of International Psychiatry
关键词 抑郁症 基因定位 候选基因
分类号 R749.4 [医药卫生—神经病学与精神病学]
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参考文献13

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  • 2Zubenko GS, Maher BS, Hughes Ⅲ HB, et al. Genomewide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early-onset, major depression. American J Medical Genetics (Neurepsychiatric Genetics), 2003; 123B: 1-18.
  • 3Zubenko, GS, Hughes Ⅲ HB, Stifller JS, et al. D2S2944 identifies a likely susceptibility locus for recurrent, early-onset,major depression in women. Mol Psychiatry, 2002; 7: 460-467.
  • 4Caspi A, Sugden K, Moffitt TE, et al. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 2003; 301: 386-389.
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  • 6Du LS, Bakish D, Hrdina PD. Tryptophan hydroxylase gene 218A/C polymorphism is associated with somatic anxiety in major depressive disorder. Journal of Affective Disorders, 2001;65 : 37-44.
  • 7Wood JG, Joyce PR, Miller A1, et al. A polymorphism in the dopamine β-Hydroxylase gene is associated with " Paranoid Ideation" in patients with major depression. Biol Psychiatry,2002; 51: 365-369.
  • 8Du KS, Bakish D, Ravindran A, et al. MAO-A gene polymorphisms are associated with major depression and sleep disturbance in males. Neuroreport, 2004; 15: 2097-2101.
  • 9Lemonde S, Turecki G, Bakish D, et al. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci. 2003;23 : 8788-8799.
  • 10Tsai SJ and Hong CJ. Pharmacogenetics of selective serotonin reuptake inhibitor respponse in major depression. Current Pharmacogenomics, 2003; 1: 1-7.

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国际精神病学杂志
2005年 第3期

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