血清碱性成纤维细胞生长因子的测定在骨肿瘤中的临床意义

Clinical Significance of Serum Basic Fibroblast Growth Factor in Patients with Bone Neoplasm

目的检测骨肿瘤患者血清碱性成纤维细胞生长因子(bFGF)的水平,探讨bFGF对良、恶性骨肿瘤的鉴别诊断意义。方法采用酶联免疫法(ELISA)检测18例良性骨肿瘤患者、21例恶性骨肿瘤患者及15例健康献血员血清bFGF的水平,并进行比较。结果恶性骨肿瘤患者血清bFGF的水平为(78.3±25.1)pg/L,明显高于良性骨肿瘤患者血清bFGF的水平[(37.4±17.1)pg/L,P<0.01]及健康对照组水平[(29.3±14.1)pg/L,P<0.01],而后两者相比较,无显著性差异(P>0.05)。结论恶性骨肿瘤患者存在bFGF的高表达,检测血清bFGF的水平有助于良、恶性骨肿瘤的鉴别诊断。

Objective To measure the serum level of basic fibroblast growth factor （bFGF） in the patients with bone neoplasms and to study its significance for differential diagnosis between benign and malignant bone neoplasms. Methods Serum bFGF levels were measured by enzyme-linked immunosorbent assay （ELISA） in 18 patients with malignant bone neoplasms and 21 patients witb benign bone neoplasms and in 15 normal subjects. Results The serum bFGF level （78.3 ± 25.1 pg/L） of the patients with benign bone neoplasm was higher obviously than that （37.4 ± 17.1 pg/L） of the patients with malignant bone neoplasms （P 〈0.01 ）, and that （29.3 ± 14.1 pg/L） of the normal subects （P 〈0.01 ）, but the difference between the latter two groups was not significant （P 〉 0.05）. Conclusion High expression of bFCF is found in the patients wth malign bone neoplasms, so its measurement is helpful to the differential diagnosis between benign and malign bone neoplasms.