缺血性脑损害对帕金森病运动症状影响的研究

Study of the effect of ischemic brain lesions on motor impairment in Parkinson's disease

目的：探讨静止性脑梗死(SCl)和脑白质损害(WML)对帕金森病(PD)运动症状的影响。方法：选取无中风史、头颅CT检查末见异常，年龄和病程配比的PD患者，观察3年后头颅MRI显示的SCl及WML的发生率及其对PD的运动功能的影响。结果：伴随高血压、糖尿病的PD患者较无伴随疾病者SCI及WML的发生率明显增高(P＜0．05)，出现SCI及WML患者的运动功能评分较无SCI及WML患者明显增加(P＜0．01)。结论：预防脑缺血损害对延缓PD病情进展、控制症状具有重要的临床意义。

Objective： To investigate the effect of ischemic brain lesions on motor impairment in Parkinson＇s disease . Methods： strict criteria for PD was used ,including no history of acute stroke and transient ischemic attack（TIA） ,absence of abnormal cerebral CT finding. Three years later , patients were performed cerebral MRI scans and motor impairment assessment by Unified Parkinson＇s Disease Rating Scale （UPDRS）. Results： The incidence of silent cerebral infarction （SCI） and white matter lesions（WMLs） in the PD patients with hypertension and diabetes is significantly higher than the patients without these accompanying disorders （P〈0.05） ,and the motor impairment in patients with SCI and WMLs is remarkably severer than the patients without SCI and WMLs （P〈0.01） . Conclusions： Aggressive prvention and treatment of ischemic cerebral vascular disease may contribute in controlling ,symptom severity in PD.