复方壬苯醇醚体外杀菌效果观察

Effect of Compound Nonoxinol on the Inhibition of Bacteria in vitro

目的:探讨壬苯醇醚和聚维酮碘合剂即复方壬苯醇醚体外协同杀菌效果。方法:将壬苯醇醚、聚维酮碘及二者混合制的复方壬苯醇醚分别对白色念珠菌和淋病奈瑟菌进行最小杀菌浓度(MBC)测定和最短杀菌时间(MBT)测定。结果:壬苯醇醚单独使用未见杀菌作用,聚维酮碘与复方壬苯醇醚杀菌时间都是2 m in,但单独使用聚维酮碘的MBC要高于复方壬苯醇醚的MBC。结论:壬苯醇醚和聚维酮碘合剂即复方壬苯醇醚有协同杀菌作用且效果优于两者单用。

Objective： To study the effect of compound nonoxinol on the inhibition of bacteria in vitro. Methods： The minimal bactericidal concentration（MBC） and minimal bactericidal time（MBT） of nonoxinol providone iodine and compound nonoxinol, composed of nonoxinol and providone iodine were determined by inhibiting C. albicans and N. gonorrhoeae. Results： Nonoxinol alone showed no inhibiting effects on bacteria. The MBT was 2 minutes for both compound nonoxinol and providone iodine, but the MBC of providone iodine was higher than that of compound nonoxinol. Conclusion ： Compound nonoxinol works better in inhibiting bacteria than either nonoxinoother or providone iodine used alone.