单侧唇裂鼻翼软骨组织学观察

Histological Conversation of the Alar Nasal Cartilages in a Unilateral Cleft Lip Fetus

目的:探讨单侧唇裂鼻畸形的形成机制,为唇裂鼻整形提供理论基础。方法:单侧唇裂流产胎儿标本1具,解剖双侧鼻翼软骨,并于鼻翼软骨内1/2处、穹隆角、外1/2处、外1/4处垂直于软骨长轴切开,水平包埋,常规组织学处理,HE染色,进行图像分析。结果:内侧角1/2处与穹隆脚处膜边和中央细胞面积、周长、等效圆直径等测量值,健患侧间无显著性差异。外侧角1/2处与1/4处膜边和中央细胞的上述指标健患侧间有差异,患侧各项均小于健侧。健侧软骨4个部位间发育无差异,而患侧间有差异。结论:单侧唇裂患侧鼻翼软骨的外侧脚细胞发育差于内侧脚及中间脚处。

Objective： To investigate the etiology of the cleft lip nose deformity and provide theory basis for cleft lip nose surgery. Methods： Gross dissection was undertaken on the alar nasal cartilages of an unilateral cleft lip stillborn fetus. Four points including medial crus 1/2 ,middle crus,lateral crus 1/2,lateral crus 1/4 of alar cartilages were embedded standardly and stained with hematoxylin and eosin, analyzed with image analysis system. Cellar areas,distribution, numbers, cartilage thickness were compared. Results： Comparing lateral and central cells＇ area, perimeter and the same eircle diameter, there were no significant differences between two sides of alar cartilages of medial crus 1/2 and middle erus. But on lateral erus 1/2 and lateral erus 1/4,There were significant difference between two sides. In normal side, there were no differences between four points of the same side. But in cleft side, there were differenees. Conclusions： There are development deficiencies in cleft lip nose lateral crus.