摘要
目的探讨伊贝沙坦洗脱支架预防动脉成形术后再狭窄的量效关系。方法把雄性新西兰白兔40只分为4组,裸支架组于腹主动脉植入裸金属支架,低剂量组植入200μg伊贝沙坦洗脱支架,中剂量组植入400μg伊贝沙坦洗脱支架,高剂量组植入600μg伊贝沙坦洗脱支架,均随访56日后取出支架作病理检查,测量血管腔面积、内膜面积、平均内膜厚度、狭窄程度。结果裸支架组血管腔面积小于3个药物支架组(P<0.05),低剂量组小于中剂量组和高剂量组(P<0.05),中剂量组和高剂量组间无明显差异(P>0.05);裸支架组内膜面积、内膜厚度、狭窄程度高于药物支架组(P<0.05);而低剂量组高于中剂量组和高剂量组(P<0.05),中剂量组和高剂量组之间无明显差异(P>0.05)。结论伊贝沙坦洗脱支架预防动脉成形术后再狭窄有量效关系。
Objicetives To search the relationship between doses and effects for preventing in-stent restenosis with irbesartan eluting stents. Methods 40 male New Zealand white rabbits were randomized divided to 4 groups： 1. bare metal stent （BMS） group： underwent bare metal stent deployment on rabbit abdominal aorta; 2. 200 μg irbesartan eluting stent （low dose group）： underwent 200 μg irbesartan eluting stent deployment on rabbit abdominal aorta; 3. 400 μg irbesartan eluting stent（middle dose group） ： underwent 400 μg irbesartan elufing stent deployment on rabbit abdominal aorta; 4. 600 μg irbesartan elufing stent （high dose group） ： underwent 600 μg irbesartan elufing stent deployment on rabbit abdominal aorta. Histopathology and histomorphometry analyses at the end of 56 days, vessel lumen area, neointimal area, average neointimal thickness and restenosis rate were recorded. Results Histopathology and histomorphometry showed that vessel lumen area was lower in BMS group than that in the other groups（P〈0.05）, low dose group were lower than middle dose group and high dose group（P〈 0.05）, there was no difference between the middle and high dose group （P 〉0.05）. Neointimal area, average neointimal thickness and area restenosis rate were higher in BMS than that in other groups （P〈 0.05）; the indexes were higher in the low dose group than that in the middle and high dose group （P〈 0.05）, they were similar in the the middle dose group and high group （P 〉0.05）. Conclusions Irbesartan eluting stent implantation shows the somewhat relationship of dosedependent effect.
出处
《岭南心血管病杂志》
2005年第5期368-371,共4页
South China Journal of Cardiovascular Diseases
