摘要
本文以人肝癌ＳＭＭＣ－７７２１细胞为材料，对水溶性灵芝提取物（ＥＧＬ）抗癌作用机理进行了研究。结果表明，ＥＧＬ能明显抑制ＳＭＭＣ－７７２１细胞的ＤＮＡ合成：ＥＧＬ在５０ｕｇ／ｍｌ到３００ｕｇ／ｍｌ范围表现出明显的剂量效应；ＥＧＬ最小有效作用剂量为１００ｕｇ／ｍｌ，最大有效作用剂量为３００ｕｇ／ｍｌ。结果提示ＥＧＬ的抗癌机理主要是通过抑制癌细胞ＤＮＡ合成而起作用的。
In this paper,the effect of EGL (Extraction of Ganoderma lucidum)on the DNA synthesis of human hepatoma cell line SMMC-7721 was studied,The results demonstrated that(1)the EGL could significantly inhibite the DNA synthesis of SMMC-7721 cells.(2)The inhibitory activity showed a possitive dose relativity from 50ug EGL/ml to 300ug EGL/ml/(3)The minimum active dose of EGL was l00ug/ml,the maximum was 300 ug/ml.From the results, we could conclude that the anticancer activity of the EGL was mainly by inhibiting DNA synthesis of the cancer cells.
出处
《中国食用菌》
1996年第1期34-35,共2页
Edible Fungi of China
关键词
芝灵
人肝癌细胞
DNA合成
抗癌机理
Ganoderma lucidum Human Hepatoma,SMMC-7721, DNA Synthesis
