nm23-H1与造血系统肿瘤关系的研究进展

Research advances on relationship between nm23-H1 and hematologic tumors

nm23-H1作为肿瘤转移抑制基因，在多种实体肿瘤中能抑制肿瘤细胞的转移和植入，与预后呈正相关，但在造血系统肿瘤研究中却发现，nm23-H1是一种分化抑制因子，具有抑制造血细胞的分化成熟，参与白血病和淋巴瘤的发生、发展过程，与预后呈负相关。

Nm23-H1, the tumor metastasis suppressor gene, can inhibit the metastasis and plant of solid tumor cells, and it is positively correlated with prognosis. However, in hematologic tumors, as a differentiation inhibiting factor, nm23-H1 inhibits differentiation and mature of hematopoietic cells and promotes the growth and development of leukemia and lymphoma. And so it is inversely correlated with prognosis.