幽门螺杆菌分型与上消化道疾病的关系

The relationship between serum classification of helicobacter pylori and chronic upper gastrointestinal diseases

目的:探讨幽门螺杆菌(Hp)分型与消化道不同疾病的关系。方法:应用免疫印迹法观察120例慢性上消化道疾病患者不同类型Hp感染的构成比。结果:Ⅰ型Hp感染者中胃炎、消化性溃疡和胃癌的构成比显著高于Ⅱ型;胃癌组的感染率高于慢性胃炎组(95.0%vs66.6%,P<0.05);消化性溃疡组的感染率(87.8%)虽比胃癌组低,但差异无显著性意义(P>0.05)。结论:应用免疫印迹法进行Hp分型有利于临床对上消化道疾病病情的判断,Ⅰ型感染者可能更有治疗的必要性。

Objective ： To study the relationship between the classification of serum Hp and chronic upper gastrointestinal diseases（UGD）. Methods： 120 patients with both Hp positive and chronic UGD diagnosed by gastroscopy were elected for the study. Patients with present Hp infection were serotyped as type Ⅰ and type Ⅱ by immunoblot technique. The percentages of chronic gastritis（ CG）, peptic ulcers （PU） and gastric cancer（GC） in patients with Hp type Ⅰ or type Ⅱ were investigated respectively. Results： In distribution, the percentages of GC, PU and GC in patients with type Ⅰ Hp infection were significantly higher than that, in patients with type Ⅱ Hp infection. The infectious rates of type Ⅰ strain in group CG, group PU and group GC were 66.6% ,8-7.8% and 95.0% ,respectively; the rate in group GC was significantly higher than that in group CG. Conclusion： Immunoblot serotyping of Hp may be a helpful index for judging the severity of chronic UGD caused by Hp infectious. It is necessary to treat type Ⅰ Hp infection.