女性吸毒人群中丙型肝炎病毒感染状况及其影响因素的研究

Study on Prevalence and Risk Factors for Hepatitis C Virus Infection among Female Drug Users

目的:了解丙型肝炎病毒在女性吸毒人群中的分布状况,并探索影响因素。方法:采用横断面研究对女性吸毒者进行流行病学调查,并用ELISA对女性吸毒者血清进行抗-HCV检测;资料用SPSS10.0、SAS软件进行统计分析。结果:女性吸毒者抗-HCV阳性率为90.9%,单因素分析表明,年龄、吸毒年限、现在吸毒方式、复吸次数是HCV感染的主要危险因素,多因素logistic回归分析表明年龄、现在吸毒方式是HCV感染的独立相关因素。结论:静脉注射吸毒是HCV感染的主要危险因素。在女性吸毒者中存在极高的HCV感染率。

Objective： To determine the status of hepatitis C virus infection and associated risk factors among female drug users, Methods： It was a cross-sectional survey in treatment of psychosocial centers in Hunan, China. Three hundred twenty female drug users were randomly selected and investigated, In order to search for the risk factors, we interviewed nose to nose all subjects. At the same time blood specimens were collected for determining antibodies against hepatitis C virus （anti-HCV） by enzyme-linked immunoadsorbent assay （ELISA）. Statistical analyses were performed by SPSS10.0 and SAS state soft. Results： The total prevalence rates of anti-HCV were 90.9%. HCV infection was associated with age, the time of using drug, injecting drug, the times of the withdrawal of drug. Using multiple logistic regression, we found that age and injecting drug remained independently relative factors with positive anti-HCV serological results. Conclusion： The primary risk factor of HCV infection was to inject drug intravenously. The prevalence rates of anti-HCV were extraordinary high among the female drug users.