氯沙坦对原发性高血压良性小动脉肾硬化血液流变性的影响

Effect of losartan on hemorrheology of hypertensive arteriolar nephrosclerosis

目的观察氯沙坦对原发性高血压良性小动脉肾硬化治疗前后血液流变性的影响。方法测定72例原发性高血压良性小动脉肾硬化(HANS)和32例对照组的血液流变学及部分肾功能指标。72例HANS患者经氯沙坦治疗使血压降至正常并持续服药达12周,比较治疗前后的血液流变学指标,并观察不良反应。结果原发性高血压良性小动脉肾硬化组全血低切粘度、全血高切粘度、血浆粘度、红细胞聚集指数、刚性指数、部分肾功能指标与对照组比较,差异有显著性(P<0.01或P<0.05);治疗组治疗前后全血低切粘度、全血高切粘度、血浆粘度、红细胞聚集指数比较差异有显著性(P<0.05)。结论原发性高血压良性小动脉肾硬化患者血液流变性减退,氯沙坦可改善其部分血液流变学指标。

Objective To observe the influence of losartan on hemorrheology after pressure having been reduced in hypertensive arteriolar nephrosclerosis （HANS）. Methods The hemorrheology and renal function were tested in 72 HANS patients and 32 healthy people （control group）. Blood pressure of 72 HANS patients were reduced to normal with treating for 12 weeks and the parameters of hemorrheology before and after treatment were compared, side effects were observed. Result The whole blood low-shear viscosity, whole blood high-shear viscosity, plasma viscosity, erythrocyte aggregation coefficient,index of rigidity of erythrocyte, some renal function in the HANS patients were signiticanfly different from those in the control group （P 〈 0.05;P 〈 0.01 ）. They except the index of rigidity of erythrocyte before treatment were significantly different （P 〈 0. 05 ; ） from those after treatment. Conclusion The hemorrheology were abnormal in HANS patients. The part of hemorrheology was improved after treatment with losartan ,there was not obvious side effects.