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转移抑制基因MRP1/CD9的研究进展 被引量：1

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摘要 MRP1/CD9属于TM4SF家族的成员,结构为细胞膜糖蛋白,有4个高度保守的跨膜结构域。研究表明MRP1/CD9对多种肿瘤的转移有抑制作用,高转移潜能肿瘤细胞MRP1/CD9低表达或不表达,低转移潜能肿瘤细胞呈相对高表达。MRP1/CD9可以作为肿瘤预后判定的一个指标,为肿瘤治疗提供了新途径。
作者 张一兵 畅继武
机构地区 天津医科大学第二医院天津市泌尿外科研究所
出处 《国外医学（泌尿系统分册）》 2005年第6期781-783,共3页 Foreign Medical Sciences(Urology and Nephrology Foreign Medical Sciences)
关键词 基因 抑制 肿瘤
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献15

  • 1Miyake M, Koyama M,Seno M, Ikeyama S. Identification of the Motilityrelated Protein(MRP-1),recognized by monoclonal antibody M31 - 15,which inhibits cell motility. J Exp Med, 1991,174:1347-54.
  • 2Ikeyama S, Koyama M, Yamaoko M, et al. Suppression of cell motility and metastasis by transfection with human motility-related protein(MRP-1/CD9) DNA.J Exp Med,1993,177:1231-7.
  • 3Eric R, Patrick B, Martine B, et al. Organization of the Human CD9Gene. Genomies, 1993,16:132 - 138.
  • 4Holden T, Maecker, Scott C,et al. The tetraspanin superfamily:molecular facilitators. The FASEB Journal, 1997,11:428-442.
  • 5Masaya O, Kazuko H, Donald A, et al. Motility Inhibition and Apoptesis Are Induced by Metastasis - suppressing Gene Product CD82 and Its Analogue CD9, with Concurrent Glycosylation. Cancer Research, 1999, (59):2335 - 2339.
  • 6Isao Tachibana, Martin E. Hemler. Roleof Transmembr Superfamily(TM4SF) Proteins CD9 and CD81 in Muscle Cell Fusion and Myotube Maintenance. The Joumal of Cell Biology, 1999,146: 893-904.
  • 7Hemler ME. Intergrin associated proteins. Curr Opin Cell Biol, 1998, (5):578 - 85.
  • 8Cheng LH, Dage L, Daiki M, et al. MRP1/CD9 gene transduction downregulates Wnt signal pathways. Oncogene,2004,23:7475-7483.
  • 9Wen Shi, Huizhou Fan, Lillian Shum, et al. The Tetraspanin CD9 Associates with Transmembrane TGFa and Regulates TGF - α induced EGF Receptor Activation and Cell Proliferation. The Journal of Cell Biology,2000,148:591 - 601.
  • 10Rubinstein E, Le Naour F, et al. CD9, CD63, CD81 and CD82 are components of a surface tetraspan network connected to HLA- DR and VLA integrins. Eur J Immunol, 1996, (11): 2657 - 2665.

同被引文献6

  • 1Ono M,Handa K,Withers DA et al.Motility inhibition and apoptosis are induced by metastasis-suppressing gene product CD82 and its analogue CD9,with concurrent glycosylation.Cancer Res,1999,59(10):2335-2339
  • 2Erovic BM,Pammer J,Hollemann D et al.Motility-related protein1/CD9 expression in head and neck squamous cell carcinoma.Head Neck,2003,25:848-857
  • 3Hashida H,TakabayashiA,Tokuhara T et al.Clinical significance of transmembrane 4 superfamily in colon cancer.Br J Cancer,2003,89:158-167
  • 4Hirano T,Higuchi T,Katsuragawa H et al.CD9 is involved ininvasion of human trophoblast-like choriocarcinoma cell line,BeWo cells.Mol Hum Reprod,1999,5 (2):168-174
  • 5Park KR,Inoue T,Ueda M et al.Anti-CD9 monoclonal antibodystimulated invasion of endometrial cancer cell lines invitro:possible inhibitory effect of CD9 in endometrial cancer invasion.Mol Hum Reprod,2000,6 (8):719-725
  • 6舒艳,谭毅,陈鸿雁.头颈肿瘤转移相关基因研究[J].中国医学文摘（耳鼻咽喉科学）,2005,20(2):73-76. 被引量：1

引证文献1

国外医学（泌尿系统分册）
2005年 第6期

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