急性出血坏死性胰腺炎犬血小板、纤溶功能的变化及四甲基吡嗪的作用

Alterations of platelet and fibrinolytic function in dogs with acute hemorrhagicnecrotizing pancreatitis with special reference to tetramethylpyrazine treat- ment

动态测定急性出血坏死性胰腺炎（ＡＨＮＰ）犬术后１、６、２４小时血浆ＧＭＰ－１４０、血小板电泳时间、ＰＡＩ和ｔ－ｐＡ活性，同时观察四甲基吡嗪（ＴＭＰ）对它们的影响。结果表明，ＡＨＮＰ犬、血浆ＧＭＦ－１４０含量、ＰＡＩ活性增高，血小板电泳时间延长，ｔ－ｐＡ活性降低，均较假手术组差异有显著性（Ｐ＜０．０５）；ＴＭＰ治疗组上述变化不显著。结果提示，犬ＡＨＮＰ早期血小板处于高度活化状态、纤溶功能降低，此可能与ＡＨＮＰ时胰腺微循环障碍、微血栓形成等病理生理现象的发生有关；

The purpose of the present study was to evaluate changes infibrinolytic system and platelet function in the early stages of acute hemorrhagic necrotizing pancreatitis(AHNP)in dogs,with special reference to granule membraneprotein (GMp- 140),platelet electrophoretic time,platelet ultrastructure,plasminogen activated inhibitor activity(PAI:a)and tissue plasminogen activitors activity(t-pA:a).Effects of tetramethylpyrazine(TMP)on the above-mentioned parameters were studiedsimultaneously. Results of present study showed that the value of plasma GMp- 140,PAI:a were much higher,platelet electrophoretic time much prolonged, and t-PA activity much lower in dogs with AHNP than those in sham-operated dogs at 1、6、24hours after induction of AHNP. Degranulation and vacuolation in platelet were alsoobserved.However,all aforementioned alterations weren,t seen in TMP treated dogs with AHNP. It was suggested that activation of platelet and decreased fibrinolytic function present in the early stages of AHNP in dogs,may be a contributing factor inthe pathogenesis of pancreatic microcirculatory disturbance and pancreatic micro-thrombosi.TMP showed its benefical effect on the preservation of platelet and fibrinolytic function in dogs with AHNP.