血清31P－核磁共振波谱（NMRS）对胃癌诊断意义的研究

Diagnostic value of serum phosphorus nuclear magnetic resonance spec-troscopy(31P-NMRS)in gastric cancer

为探讨３１Ｐ－核磁共振波谱（ＮＭＲＳ）对胃癌诊断的可行性，采用ＶＸＲ－３００超导核磁共振仪测量人血清标本１１４例，其中胃癌５６例，健康对照５８例，分析比较了它们各自的三个主要谱峰ａ、ｂ和ｃ。结果发现，二组间谱峰的化学位移Ｓａ、Ｓｂ、Ｓｃ相差很小（０．５〉Ｐ〉０．２）。谱峰强度则有明显变化。计算谱峰ａ与谱峰ｂ和ｃ的总面积积分值之比（ａ／ｂｃ），胃癌组与对照组ａ／ｂｃ的均值分别为０．１８８±０．

The aim of this study is to investigate the feasibility of serum31P-NMRS in diagnosis of gastric cancer. Serum sample of 114 cases were collected andtheir31P-NMRS measured with VXR-300 MHZ spectrometer. There were 56 cases withgastric cancer and 58 cases as healthy controls. The spectrum had a,b and c parts.Their chemical shifts did not show any difference(0.5 > P> 0.2),but there wasalteration in spectrum intensity between patients with gastric carcinoma and healthycontrols. The ratio of the integrated areas of a and bc was calculated and showed thatthere was significant difference between the carcinoma group(0.188 ± 0.053)andcontrol grouop(0.1 10 ± 0.037),P< 0.001.The sensitivity of this method was 80.36 %,specificity was 81.03%. These results suggest that serum 31P-NMRS may likely becomea promising new method for identifying the presence of gastric cancer.