季铵盐参与的直接化学选择性O-和N-烷基化反应

Chemoselective O-and N-alkylation from Quaternary Ammonium Salt

将羧酸或胺类化合物与季铵盐进行简单的混合加热,便可直接得到O-或N-烷基化产物。季铵盐中烷基的转移具有较好的选择性,其优先顺序为:苄基>伯烷基>仲烷基。

O- or N-alkylation was carried out directly by simple heating the mixture of carboxylic acid or amine with quaternary ammonium salt. Excellent selectivity in alkyl transfer was noted in the sequence of PhCH2 〉 primary alkyl 〉 secondary alkyl.