上海市区胰腺癌全人群病例对照研究──胰腺癌与烟、酒、绿茶的关系

TOBACCO,ALCOHOL AND GREEN TEA CONSUMPTION AND PANCREATIC CANCER:A POPULATION-BASED CASE-CONTROL STUDY IN URBAN SHANGHAI,CHINA

在上海市区进行的基于全人群的胰腺癌病例对照研究中，共访问了４５１例病人和１５５２例对照。研究表明在吸烟人群中发生胰腺癌的危险性上升，男女性的相对危险度（用比数比ＯＲ近似）分别为１．５（９５％可信限：１．１～２．１）和１．５（９５％可信限：０．９～２．５）．并且随着每天吸烟的支数、吸烟的年限及包年数增加而升高，但随着开始吸烟的年龄或戒烟年数的上升而下降。男女饮酒的ＯＲ值无统计学上显著性意义。在调整了年龄、经济收入和每天吸烟支数之后，发现饮绿茶的女性发生胰腺癌的危险性有显著性的下降（ＯＲ＝０．５．９５％可信限：０．３～０．７）．但在男性中，仅在中度饮绿茶者中观察到危险性下降（ＯＲ＝０．６，９５％可信限：０．４～１．０）有显著性意义。

A population-based case-control study of pancreatic cancer was carried out in urban Shanghai including 451 cases and 1552 controls interviewed.Risk of pancreatic cancer was increased among tobacco smokers and decreased among green tea drinkers. Odds ratios (OR) for smoking were 1.5(95%CI:1.1～2.1)and 1.5(95%CI: 0.9～2.5) for men and women respectively, and increased with number of cigarettes smoked per day,duration of smoking,number of packyears,and decreased with age started smoking and years stopped smoking.For both males and females,the ORs for alcohol drinking were not statistically significant.After adjustment for age,income,and cigarette smoking,a statistically significant protective effect of green tea drinking on pancreatic cancer was observed among women(OR =0.5,95%CI:0.3～0.7),but a significant reduced risk(OR = 0.6,95%CI:0.4～1.0) was only observed in heavier drinkers of green tea among men.