滋养细胞肿瘤子宫动脉灌注化疗13例分析

Uterine arterial infusion chemotherapy for trophoblastic tumor:A report of 13cases

目的:探讨超选择性子宫动脉灌注化疗治疗滋养细胞肿瘤的方法及疗效。方法:33例患者随机分为两组,一组接受超选择性子宫动脉插管持续灌注化疗,另一组接受全身化疗,观察两组疗效和毒副反应。结果:介入治疗中骨髓抑制率低于全身化疗组(P=0.050～P=0.009),病灶缩小及血βhCG下降程度高于全身组(P=0.013,P=0.027)。结论:超选择性子宫动脉灌注化疗滋养细胞肿瘤疗效明确,且毒副反应较静脉化疗轻。

Objective： To evaluate the efficacy of uterine artery infusion chemotherapy on trophoblastic tumor. Methods： Thirty-three patients were randomly divided into two groups. One group were treated by uterial infusion chernotherapy and the other received venous ehernotherapy. The therapeutic effects and the toxic and side effects of the two groups were analyzed and compared. Results： The rate of mydosuppression in the arterial interventional group was lower than that in the venous chemotherapy group（P = 0.050 to P= 0. 009）. The carcinoma size reduced and the level of serum β-hCG decreased obviously in the arterial interventional group compared with the ehernotherapy group（P = 0. 013, P = 0. 027 ）. Conclusions： The uterine arterial infusion chemotherapy is effective for trophoblastie tumor and the toxic and side effects are smaller than that by venous chemotherapy.