脑梗死患者循环活化血小板FIB-R的检测及其临床意义

Clinical significance of fibrinogen receptor expression on circulating activated platelets in patients with cerebral infarction

目的:探讨血液中循环活化血小板(circulating activated platelets,CAP)的纤维蛋白原受体(fibrinogenreceptor,FIBR)在脑梗死患者中的临床意义。方法:用流式细胞术检测10名正常人、20例有血栓形成倾向和20例急性脑梗死患者治疗前后血小板FIBR的表达量。结果:有血栓形成倾向和急性脑梗死患者治疗前的血小板FIBR表达量明显高于正常人(P<0.01)。急性脑梗死患者治疗前后血小板FIBR表达差异有显著性(P<0.01)。结论:流式细胞术检测FIBR能准确反映体内血小板的活化水平,对脑梗死的预测、治疗、疗效监测、预后判断有重要意义。

Objective： To explore the clinical significance of the fibrinogen receptor（FIB-R） expression on the circulating activated platelets（CAP） in patients with cerebral infarction. Methods： The levels of FIB-R expression on CAP were detected by flow cytometry （FCM） in the blood of 10 healthy controls,20 patients with thrombotic tendency and 20 patients with acute cerebral infarction before and after treatment. Results： The FIB-R expression levels on CAP were markedly higher（P 〈 0.01） in patients with thrombotic tendency and the ones with acute cerebral infarction than that in the healthy oontrols. The expression levels of FIB-R on CAP before and after treatment were significantly different（P〈0.01）. Conclusions：The level of platelet activation can be reflected accurately by detection of FIB-R expression on CAP, which is of great value for the prediction, treatment, supervision of curative effect and estimation of prognosis in patients with cerebral infarction.