骨髓异常增生综合征骨髓涂片检查误诊分析

Analysis of misdiagnosis of myelodysplastic syndrome by bone marrow smears

目的:分析骨髓异常增生综合征(myelodysplasticsyndrome,MDS)骨髓涂片检查误诊原因。方法:对1992年2月～200年12月我院误诊MDS47例骨髓涂片进行回顾性分析。结果:难治性贫血误诊率最高达89.3%,主要误诊病种为增生性血、慢性再生障碍性贫血、巨幼红细胞性贫血、急性白血病等。结论:MDS诊断较为困难,应仔细结合病史、骨髓活检及细胞传学检查才能作出正确诊断。

Objective： To analyze the causes of misdiagnosis of myelodysplastic syndrome（MDS） by bone marrow smears. Methods： Fortyseven patients with MDS misdiagnosed by bone marrow smears from February 1992 to December 2003 were analyzed retrospectively.Results：The misdiagnosis rate of refractory anemia（RA） reached 89.3 %. The major misdiagnosed diseases were proliferous anemia （PA）, chronic aplastic anemia （CAA）, megaloblastic anemia （MA） and acute leukemia （AL）. Conclusions： The diagnosis of MDS is relative difficult and correct diagnosis can be made by means of analysis of the patients＇ medical history, bone marrow biopsy and cytogenetics.