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新斯的明对颈丛阻滞下甲状腺手术中心血管反应的治疗作用

Effect of neostigmine on cardiovascular response during cervical plexus block anesthesia of thyroid surgery
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摘要 目的观察新斯的明治疗颈丛阻滞下甲状腺手术中心血管反应的有效性和安全性。方法60例ASAⅠ~Ⅱ级于颈丛阻滞下行甲状腺手术的患者,对其中发生室上性心动过速的25例患者予以静脉注射0.008mg/kg的新斯的明,观察新斯的明应用前、应用后5、10、30、60min时心率(HR)、血压(BP),计算心率收缩压乘积指数(RPP)。并观察新斯的明应用后的不良反应。结果新斯的明静脉注射后5minHR即显著下降(P<0.05),RPP亦显著下降(P<0.05),其中用药后30minHR和RPP降到最低(P<0.05),其降幅分别达47.6%和57.9%。用药后60min时HR有所上升,但仍显著低于用药前(P<0.05)。所有患者未见不良反应发生。结论新斯的明治疗颈丛麻醉下甲状腺手术中心血管反应安全、有效,但要选择病例。 Objective To evaluate the efficacy and safety of neostigmine on cardiovascular response during cervical plexus block anesthesia of thyroid surgery. Methods Twenty five of sixty ASA Ⅰ~Ⅱpatients aged 20~58 years during cervical plexus block anesthesia of thyroid surgery, who undergone supraventricular tachycardia, were treated with 0.008mg/kg neostigmine intravenously. The variation of heart rate (HR)and blood pressure (BP) were recorded before administered neostigmine and after five, ten, thirty, sixty minutes, and the rate-pressure product (RPP) were computed. The adverse effects during operations were recorded.' Results HR and RPP significantly fell during five minutes after neostigmine being injected(P〈0.05), the lowerest HR were observed at thirty minutes after injected (P〈0.05), the fell extent of HR and RPP were 47.6% and 57.9%. HR rose at sixty minutes after injected but significantly lower than before injected(P〈0.05). No severe adverse effects were observed in all patients. Conclusion Neostigmine can safely and effectively treats cardiovascular response during cervical plexus block anesthesia of thyroid surgery, but the patients must be elected.
出处 《江西医药》 CAS 2005年第10期609-610,共2页 Jiangxi Medical Journal
关键词 新斯的明 颈丛阻滞 甲状腺手术 心血管反应 neostigmine cervical plexus block thyroid surgery cardiovascular response
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