两种不同浓度的氦氧混合气体改善缓解期慢阻肺病患者缺氧症状的效果比较

Effects of helium-oxygen mixture with two different concentrations on anoxia symptoms in COPD patients at the remission stage

目的:比较两种不同浓度的氦氧混合气体改善缓解期慢阻肺病患者缺氧症状的效果。方法:分别让两组缓解期慢阻肺病患者呼吸含60%氦和含80%氦的氦氧混合气体并测定比较其呼吸氦氧气体前后肺活量及其组成的变化。结果:两组慢阻肺病患者基础肺功能测定结果差异无显著性(P>0.05);各自呼吸不同浓度的氦氧混合气体后,肺活量及其组成两组相比较差异也无显著性(P>0.05);且其增加或减低的变化百分率差异也无显著性(P>0.05)。结论:含60%氦的较低氦浓度的氦氧混合气体与含80%氦的氦氧混合气体一样具有改善慢阻肺患者缺氧症状的作用,从降低成本的角度考虑,可采用较低氦浓度的氦氧混合气体对慢阻肺患者进行氧疗或康复治疗。

Objectives To observe the effects of the helium-oxygen mixture with two different concentrations on anoxia symptoms in COPD patients at the remission stage. Methods 44 patients with COPD at the remission stage were divided into two groups, breathing helium-oxygen mixture containing 60% （GroupⅠ） and 80% （GroupⅡ） helium respectively. Changes of vital capacity as well as its components were assessed before and after breathing helium-oxygen mixture. Results There was no significant difference between two groups in lung function, vital capacity and its components after breathing helium-oxygen mixture with different concentration （P〉0.05）. There was no significant difference between two groups in increasing or decreasing percentages of vital capacity and its components（P〉0.05）. Conclusions The helium-oxygen mixture containing 60% helium could improve anoxia symptoms as well as helium-oxygen mixture containing 80% helium in COPD patients. It is suggested that helium-oxygen mixture with lower helium concentration can be used in oxygen therapy or rehabilitation therapy in COPD patients and decrease its clinical costs.