香丹注射液加入不同的液体中不溶性微粒污染的实验研究

An experimental study on insoluble particles contamination by dispensing Xiangdan injection in different infusion fluids

[目的]了解香丹注射液静脉输注时不溶性微粒污染情况。[方法]用两种不同的配药方法,将香丹注射液分别与生理盐水、5%葡萄糖、10%葡萄糖、5%葡萄糖氯化钠、6%右旋糖酐-40注射液配伍,在配伍后5min、30min、60min、120min时测定液体中不同微粒直径的不溶性微粒数。[结果]香丹注射液与5种输液液体配伍后不溶性微粒显著增加,尤以在6%右旋糖酐-40注射液中增加最为显著;配药方法、放置时间与不溶性微粒密切相关。[结论]选择适宜输液液体、规范配伍程序、现用现配是减少不溶性微粒污染的重要措施。

Objective： To find the insoluble particles contamination in patients undergoing Xiangdan injection intravenous transfusion. Method： Two different ways of dispensing were adopted, Xiangdan injection were mixed in 0.9% sodium chloride, 5% glucose, 10% glucose, 5% sodium chloride and glucose, and 6 % dextran- 40 solutions respectively. Then, numbers of insoluble particles at different diameters in all solutions were measured 5 minutes, 30 minutes, 60 minutes and 120 minutes later respectively. Result：Insoluble particles increased obviously when mixed Xiangdan injection in all five different solu- tions. However, it was most remarkable when mixed Xiangdan injection in 6 % dextran- 40. Both ways of dispensing and time of placement were closely correlated to insoluble particles. Conclusion：For the purpose of reducing insoluble particles, one should choose correct injections, standardize the processes of dispensing and use injections right after dispensing.