天津商学院学生结核感染者预防性用药效果分析

The Effect Analysis of the Preventative Drugs for Tuberculosis Infected Students in Tianjin University of Commerce

目的了解大学生结核感染者预防性用药情况。方法由天津市结核病控制中心、天津商学院校医院预防科医生和学生红十字会会员分工管理,对2001-2004级入学新生12657名中PPD试验强阳性,而胸部X线检查正常的2063名进行预防性用药。用药方案为雷米封:0.3g每日1次,饭后服用;肌苷片:每次2片,每日3次,饭后服用。两药均需服用3个月。结果本着自愿服药的原则,2063人中实际来医院领药的有1158人,而完成了规定疗程的有801人,占领药人数的56.13%,占应服人数的38.82%。用药学生中发生药物不良反应17名,发生率为1.47%。其余人员因种种原因不能坚持。同时对4年结核病发病情况分析可见,新发结核病与入学PPD试验结果之间没有必然联系。结论大学生结核感染者预防性用药存在的主要问题:一是疗效不明显,二是疗程较长,学生坚持用药和监督管理存在困难,往往中途停药;三是单用雷米封易发生耐药及不良反应。建议在大学生中采取健康教育、接种卡介苗以降低结核病发病率,并建议探索预防性服药方案。

Objective To know the situation of the preventative drugs for tuberculosis infected college students. Method To give the preventative drugs to 2063 new students among 12 657 in 2001-2004 Grade, whose PPD test is strong masculine and breast X line test is natural. Prescription of dosing： Rimifon, take 0.3g after every meal, once a day; Inosine Tabletes, take two tablets after every meal, three times a day. Those two medicines all dose three months. Results In the principle of volunteer dosing, there are 1158 students among 2063 who take medicine from hospital, but there are only 801 students who fulfilled prescriptive period of treatment, which occupy 56.13% in students taking medicine and occupy 38.82% in students dosing medicine. 17 students among students dosing medicine have medication evil effect, which probability is 1.47%. Other students didn＇ t persist in for several reasons. At the same time, to analyze the illness condition of tuberculosis for four years, we can conclude that there is not necessary relation between the resent tuberculosis and PPD test results in university entrance. Conclusion The preventative drugs for tuberculosis infected college students have problems： the first is curative effect is inconspicuous; the second is the period of treatment so longer that the students always generate stop dosing halfway; the third is only dosing Rimifon easily happens anti-drugs and badness effects. We propose to adopt integrate measures to reduce the incidence of the tuberculosis, for example, health education, inoculate beg vaccine, dose preventatively.