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CYP4A/20-HETE在VEGF活化eNOS及调节肺血管节律作用的分子机制 被引量：2

CYP4A/20-HETE's moleculay mechanism in VEGF activating eNOS and regulating pulmonary vascular rhythm
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作者 朱大岭 毕海荣 唐晓波
机构地区 哈尔滨医科大学药学院
出处 《中国药物与临床》 CAS 2005年第9期648-649,共2页 Chinese Remedies & Clinics
基金 国家自然科学基金资助项目(30470752)
关键词 CYP4A/20-HETE 细胞活化 ENOS 肺血管 血管节律 分子机制 一氧化氮 血管内皮生长因子
分类号 R363 [医药卫生—病理学]
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参考文献8

  • 1Roman LJ,Palmer CNA,Clark JE,et al.Expression of rabbit cytochromes P450 4A which catalyze the ω-hydroxylation of arachidonic acid,fatty acids,and prostaglandins. Arch Biochem Biophys, 1993,307:57-65.
  • 2Roman RJ.P450 metabolites of arachidonic acid in control of cardiovascular function. Physiol Rev, 2002,82(1):181-185.
  • 3Zhu D,Zhang CY,Meetha-Medhora M,et al. CYP4A Mrna,protein,and product in rat lungs:novel localization in vascular endothelium.J Appl Physiol,2002, 193:330-337.
  • 4Villamor E,Le Cras TD,Horan MP.Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in pulmonary hypertension. Am J Physiol , 1997,272:L 1013-1020.
  • 5Steudal W,Ichinose F, Huang PL.Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase ( NOS3 )gene. Circ Res, 1997,81:34-41.
  • 6Fontana J, Fulton D, Chen Y, et al. Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phos phorylation of endothelial nitric oxide synthase and NO release. Circ Research,2002,90:866-873.
  • 7Liu MH,Jin H,Floten HS,et al.Vascular endothelial growth factor-mediated,endothelium-dependent relaxation in human internal mammary artery.Ann Thoracic Surg,2002,73 (3):819-824.
  • 8Uhlmann S,Friedrichs U,Eichler W,et al. Direct measurement of VEGF-induced nitric oxide production by choroidal endothelial cells. Microvascular Research,2001,62(2):179-189.

同被引文献42

  • 1Lasker JM, Chen WB, Wolf 1. et al. Formation of 20 hydroxyei cosaletraenoic acid, a vasoactivc and naturiurc eicosanoid in hu man kidney, Role of CYP4F2 and CYP4All [J].J Biol Chem 2000, 275 (6), 4118 4122.
  • 2Roman RJ. P 50 metaboliles of arachidonic acid in the controlof cardiovascular function [J]. Physiol Rev, 2002, 82 ( 1), 131-185.
  • 3Miyata N, Roman RJ. Role of 20-hydroxyeicosatetraenoic acid in vascular system [J].J Smooth Muscle Res, 2005, 41 (4): 175 -193.
  • 4Honeck H, Gross V, Erdmann B, et al. Cytochrome P450 dependent renal arachidonic acid metabolism in DOCA-salt hy pertensive mice [J]. Hypertension, 2000, 36 (4): 610 -616.
  • 5Shatara RK, Quest DW, Wilson TW, et al. Fenofibrate lowers blood pressure in two geneticmodels of hypertension [J]. Can J Physiol Pharmacol, 2000, 78 (5): 367- 371.
  • 6Kumar NN, Benjafield AV, Lin RC, et al. Haplotype analy sis of aldosterone synthase gene (CYPllB2) polymorphismsshows association with essential hypertension [J]. J Hyper tens, 2003, 21 (7): 1331-1337.
  • 7Gebremedhin D, Lange AR, Lowry TF, et al. Production of 20-HETE and its role in autoregulation of cerebral blood flow [J].CircRes, 2000, 87 (1): 60-65.
  • 8Randriamboavonjy V, Busse R, Fleming I. 20 HETE induced contraction of small coronary arteries depends on the activation of Rho kinase [J]. Hypertension, 2003, 41 (3): 801- 806.
  • 9Mulligan SJ, MacVicar BA. Calcium transients in astrocyte endfeet cause cerebrovascular constrictions [ J 1-Nature, 2004, 431 (9): 195-199.
  • 10Zhao X, Imig JD. Kidney CYP450 enzymes:biological actions beyond drug metabolism EJ].Curr Drug Metab, 2003, 4 (1): 73-84.

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二级引证文献8

中国药物与临床
2005年 第9期

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