端粒保护蛋白

Protection of Telomere 1

端粒保护蛋白(protectionoftelomere1,POT1)是存在于人和裂殖酵母的端粒相关蛋白,特异性地与端粒单链DNA相结合。人POT1基因位于7号染色体上,由22个外显子组成,其中4个外显子属于跳跃外显子,可形成5个剪接变异体。POT1的功能在于维持端粒的稳定,通过TRF1-TIN2-PIP1-POT1通路调节端粒长度。

Protection of telomere 1 （POT1） is a single-stranded telomeric DNA binding protein identified in fission yeast and human, which binds specifically to the G-rich telomere strand. Human POT1 gene contains 22 exons, four of which are subject to exon skipping in some transcripts, giving rise to five splice variants. POT1 is proposed not only to participate in telomere maintenance, but also to recruit telomerase to the ends of chromosomes. POT1 plays functions in telomere maintenance and stability, through TRF1-TIN2-PTOP-POT1 pathway on control of telomere length by telomerase.