摘要
Both HIV and EIAV belong to the retroviridae family and lentivirus genus. They share considerable simi- larity at gene structural and component level. Hotzel pro- posed that two variable regions and surrounding amino acids of EIAV gp90 might adopt the same topology as V1, V2 and bridging sheet of HIV gp120. These regions map to V3, V4 and surrounding amino acids of EIAV gp90. Based on this proposal, we further analyzed the distribution profile of N-glycosylation site and linear epitope for EIAV gp90 and HIV gp120 at these regions. Our results demonstrated that EIAV gp90 and HIV gp120 are highly similar at these two aspects. Most likely, V3, V4 and surrounding amino acids of EIAV gp90 adopt the same topology structure as V1, V2 and bridging sheet of HIV gp120.
Both HIV and EIAV belong to the retroviridae family and lentivirus genus. They share considerable similarity at gene structural and component level. Hotzel proposed that two variable regions and surrounding amino acids of EIAV gp90 might adopt the same topology as V1, V2 and bridging sheet of HIV gp120. These regions map to V3, V4 and surrounding amino acids of EIAV gp90. Based on this proposal, we further analyzed the distribution profile of N-glycosylation site and linear epitope for EIAV gp90 and HIV gp120 at these regions. Our results demonstrated that EIAV gp90 and HIV gp120 are highly similar at these two aspects. Most likely, V3, V4 and surrounding amino acids of EIAV gp90 adopt the same topology structure as V1, V2 and bridging sheet of HIV gp120.
基金
supported by Ministry of Science and Technology of China(First Stage
Grant No.2001 CCA00600)
supported by the National Science Foundation of China(Grant No.30371319).
