乳腺癌与心理社会危险因素的相关性研究

Study on the psychosocial risk factors of breast cancer

目的探讨与乳腺癌发病有关的危险性心理社会因素。方法对临床确诊的31例乳腺癌病人及31例正常人,进行心理行为问卷(婚姻质量问卷—ENRICH、生活事件问卷—LES、社会支持评定量表—SSRS和特质应对方式—TCSQ)测试。结果在乳腺癌确诊前5年内病人所经历的应激性负性生活事件(L2)明显多于对照组,其中以与家庭有关的负性生活事件(L5)及工作学习中的问题(L8)占主要位置,且病人的婚姻满意度(H5)低于对照组,在遇到应激性负性生活事件时较多地采用消极的应对方式(NC),以上差异均有统计学意义(P<0.05)。从条件Logistic回归分析选入变量中,L5[OR=0.959,CI(0.921～0.998)]、S2[OR=0.825,CI(0.700～0.972)]和NC[OR=0.921,CI(0.847～1.002)]与乳腺癌的发病危险性关系密切。结论病前经历较多的与家庭有关的应激性负性生活事件、面对应激时缺乏客观社会支持及采取消极的应对方式是女性发生乳腺癌的重要危险因素之一。

Objective ： To investigate the psyohosooial risk factors of breast cancer. Methods ： 31 diagnosed patients with breast cancer and matched 31 normal health women entering the study were requested to test the psychological rating scales（LES, SSRS, ENRICH, TCSQ）.Results ： The patients had experienced significantly more stressful life events,and had lower quality in marriage, and more often used negatively coping style than the controls （ P 〈0.05）, during the last 5 years before diagnosis. The conditioned Logistic regressive analysis found that the important variables that had significant relationship with breast cancer were stressful life events,objective social support and negative coping style. Conclusion： Psychosoclal stressful factors,such as stressful life events, lack of available psychosocial supPort,and negative coping styles are one of the important risk factors in the onset and progression of breast cancer in women.