急性脑梗死与相关分子标记物的研究

Clinical study of related molecular markers of cerebral infarction

目的测定脑梗死患者血浆中总蛋白S(TPS)、组织型纤溶酶原激活剂(t-PA)、血管性血友病因子(vWF)及纤维连接蛋白(Fn)含量,以探讨这些分子标记物与脑梗死之间的关系。方法均采用ELISA法测定脑梗死患者与正常对照组血浆中TPS、t-PA、vWF和Fn的含量。结果脑梗死患者血浆中TPS和t-PA含量较正常对照组低(P<0.01或0.05),有统计学意义;脑梗死患者血浆中vWF和Fn含量较正常对照组高(P<0.01),有显著差异。结论血浆中总蛋白S、组织型纤溶酶原激活剂、血管性血友病因子及纤维连接蛋白量变化与脑梗死的发病密切相关。

Objective To measure the concentration of total proteinS （ TPS）, tissue plasminogen activator （ t-PA）, von Willebrand factor （vWF） and fibronection （Fn） in plasma in patients with cerebral infarction and to investigate the relationship between those molecular markers and cerebral infarction. Methods The concentration of TPS, t-PA, vWF and Fn in plasma in patients and normal control group were measured by enzyme-linked immunosorbent assay（ELISA）. Results The concentration of TPS and t-PA in plasma in patients were much lower than those normal subjects, P 〈 0.01 or 0.05. It has remarkable significane. Conversely, the level of vWF and Fn were significantly higher in the patients than in the controls（ P 〈 0.01 ）. There were marked difference. Conclusion The variety of the concentration of TPS, t-PA vWF and Fn in plasma has a great relationship with the attack of cerebral infarction.