肺癌患者血淋巴细胞多环芳烃羟化酶的诱导性

Inductivity of aryl hydrocarbon hydroxylase in lymphocytes of patients with lung carcinoma

采用荧光分光光度法测定２９例肺癌患者和３０例肺部良性疾病患者培养血淋巴细胞多环芳烃羟化酶（ＡＨＨ）活性及诱导性。结果发现肺癌患者的血淋巴细胞ＡＨＨ诱导性（３．７８±０．９９）与健康人的（２．３６±０．７９）和肺部良性疾病患者的（２．３９±０．７４）相比均有极显著性差异（Ｐ＜０．０１）。将诱导性分为高、中、低三种类型，健康人的高、中、低诱导性分别为：９．６８％，３２．３６％和５８．０６％；肺部良性疾患组分别为：１０．００％，４３．３３％和４６．６７％，而肺癌组分别为：５５．１７％，３４．４８％和１０．３５％，结果表明肺癌组高、中诱导性的多，低诱导性的少，提示：肺癌的易感性可能与人血淋巴细胞ＡＨＨ高诱导性有关；检测人血中ＡＨＨ诱导性将有助于筛选肺癌的易感人群及肺癌的预防。

The inductivity of aryl hydrocarbon hydroxylase(AHH)in cultured human lymphocytes were determined in 29 patients with lung carcinoma and 30 patients with lung benign diseases with the fluorometry method.The results showed that MC,as an inducer,can increase the AHH activity.AHH inductivity(ratio of induced activity and basal activity)in the patients with lung carcinoma(3.78±0.99)was significantly higher(P<0.01)than that in the healthy control(2.36+0.79)and that of the patients with lung benign diseases(2.39±0.74).The normal population can be divided into three separate groups having high,intermediated and low inducible aryl hydrocarbon hydroxylase activities,with of frequencies of 9.68%,32.36% and 58.06% respectively.The frequencies of the three groups were 10.00%,43.33% and 46.67%,respectively in the patients with lung benign disease;55.17%,34.48%and 10.35%,in the patients with lung carcinoma.The comparison of the distribution of phenotypes in the normal population and the patients with lung diseases with that in the patients with lung cancer,showed that the differences are highly significant(p<0.01).Especially striking is the virtual absence of the cases of lung cancer in the low inductivity group.The data indicate that the susceptibility to lung carcinoma may be associated with the higher levels of inducible AHH activity.