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热休克蛋白gp96与肿瘤免疫研究进展 被引量：3

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摘要 热休克蛋白gp96作为分子伴侣参与了肿瘤抗原向MHC-I类分子途径的递呈过程,并与抗原肽形成gp96-肽复合物激活CD8+T淋巴细胞,产生抗肿瘤的特异性免疫反应。此外,还能不依赖于抗原肽通过激活NF-κB信号转导,产生细胞因子和趋化因子,诱导树突状细胞成熟等多种作用而调节非特异性免疫反应。gp96-肽复合物疫苗为肿瘤的免疫治疗提供了新的思路。
作者 马小兵 畅继武
机构地区 [ 天津市泌尿外科研究所肿瘤免疫研究室
出处 《国外医学（免疫学分册）》 2005年第6期373-376,共4页 Foreign Medical Sciences(Section of Immunology Foreign Medical Sciences)
基金 天津市自然科学基金资助项目(043608411)
关键词 GP96 肿瘤免疫 抗原递呈
分类号 R730.3 [医药卫生—肿瘤]
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参考文献19

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同被引文献23

  • 1肖刚,文剑明.热休克蛋白与肿瘤免疫[J].国外医学（生理病理科学与临床分册）,2004,24(4):303-305. 被引量：3
  • 2汤宇,袁玫,卢世璧.热休克蛋白与肿瘤免疫治疗[J].中国肿瘤临床与康复,2004,11(5):470-472. 被引量：2
  • 3CandiH MM,Li Z.HSPPC-96:a personalized cancer vaccine[J].Expert Opin Biol 3her,2001,1(3):539-547.
  • 4Srivastava PK.Hypothesis:Controled necrosis∞ awolforimmunothem-PY ofhuman cancer[J].Cancer Imlmm,2003,(3):4.
  • 5Kamal A,Th an L,Sensintafar J,et a1.A high-affinity conform ation of Hsp90 confers tumour selectivity on hsp90 inhibitors[J].Nature,2003,425:407-410.
  • 6Castelli C,Rivoltini L,Rini F,et a1.Heat shock proteins:bid0gieal runetions and di~eal application∞ personalized vaccines for human c∞cef[J].CKncer lmmunol lmmunother,2004,53(3):22-23.
  • 7SIEGEL R,NAISHADHAM D, JEMAL A. Cancer statistics[J]. CA Cancer J Clin, 2012,62(1):10-29.
  • 8JHAVERI K,TALDONE T, MODI S,et al. Advances in theclinical development of heat shock protein 90 (Hsp90) inhibi-tors in cancers [J]. Biochim Biophys Acta, 2012, 1823(3):742-755.
  • 9WANG Q,AN L, CHEN Y, et al. Expression of endoplasmicreticulum molecular chaperon GRP94 in human lung cancer tis-sues and its clinical significance [J]. Chin Med J (Engl), 2002,115(11):1615-1619.
  • 10GALLERNEC, PROLA A, LEMAIREC. Hsp90 inhibition byPU-H71 induces apoptosis through endoplasmic reticulum stressand mitochondrial pathway in cancer cells and overcomes theresistance conferred by Bcl-2 [J]. Biochim Biophys Acta,2013, 1833(6):1356-1366.

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国外医学（免疫学分册）
2005年 第6期

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