179株粘质沙雷菌的分布及耐药性分析

Distribution Characteristics and Resistant Analysis of 179 Strains of Serratia Marcescens

目的:了解粘质沙雷菌感染的分布及耐药性特征,为临床用药提供依据。方法:收集我院1998年～2004年分离的179株粘质沙雷菌的药物敏感性试验结果,进行细菌的分布及耐药性的分析。结果:分离的179株粘质沙雷菌,其中痰标本有135株(占75.4%);粘质沙雷菌分离数不断增加;其耐药率>95%的抗菌素有头孢噻吩、头孢唑啉和头孢呋肟;50%～70%的有氨苄西林、氨苄西林/舒巴坦和头孢泊肟;10%～20%的有哌拉西林、哌拉西林/他唑巴坦、三代头孢菌素和四代头孢菌素;<10%的有亚胺培南、阿米卡星、庆大霉素、复方新诺明和环丙沙星。结论:粘质沙雷菌耐药机制复杂,而且对抗生素具有多重耐药性,根据药敏试验合理应用抗菌素十分重要。

Objective： To investigate distribution characteristics and resistant analysis of Serratia marcescens. Methods： 179 strains of Serratia marcescens, which were separated from West China Hospital during 1998 and 2004, were identified and susceptibility using the MicroScan WalkAway 40. Results： 179 strains were mainly separated from sputum. Its isolates was increased. Antibiotics which rate was more than 95% were cephalothin, cefazolin and cefuroxime. Antibiotics which rate was between 50% and70% were ampicillin, ampicillin- sulbactam and cefpodoxime. Antibiotics which rate was between 10% and 20% were piperacillin, pieperacillin - tazobactam, 3^st and 4^nd generation cefolosporins. Antibiotics which rate was less than 10% was imipenem, amikacin, gentamicin, trimethoprim - sulfamethoxazole and ciprofloxacin. Conclusions ： Resistant mechanism of Serratia mareescens was complex, and it showed multi - drug resistant. It is very important to rationally use antibiotics according to susceptibility testing results.