摘要
目的:了解粘质沙雷菌感染的分布及耐药性特征,为临床用药提供依据。方法:收集我院1998年~2004年分离的179株粘质沙雷菌的药物敏感性试验结果,进行细菌的分布及耐药性的分析。结果:分离的179株粘质沙雷菌,其中痰标本有135株(占75.4%);粘质沙雷菌分离数不断增加;其耐药率>95%的抗菌素有头孢噻吩、头孢唑啉和头孢呋肟;50%~70%的有氨苄西林、氨苄西林/舒巴坦和头孢泊肟;10%~20%的有哌拉西林、哌拉西林/他唑巴坦、三代头孢菌素和四代头孢菌素;<10%的有亚胺培南、阿米卡星、庆大霉素、复方新诺明和环丙沙星。结论:粘质沙雷菌耐药机制复杂,而且对抗生素具有多重耐药性,根据药敏试验合理应用抗菌素十分重要。
Objective: To investigate distribution characteristics and resistant analysis of Serratia marcescens. Methods: 179 strains of Serratia marcescens, which were separated from West China Hospital during 1998 and 2004, were identified and susceptibility using the MicroScan WalkAway 40. Results: 179 strains were mainly separated from sputum. Its isolates was increased. Antibiotics which rate was more than 95% were cephalothin, cefazolin and cefuroxime. Antibiotics which rate was between 50% and70% were ampicillin, ampicillin- sulbactam and cefpodoxime. Antibiotics which rate was between 10% and 20% were piperacillin, pieperacillin - tazobactam, 3^st and 4^nd generation cefolosporins. Antibiotics which rate was less than 10% was imipenem, amikacin, gentamicin, trimethoprim - sulfamethoxazole and ciprofloxacin. Conclusions : Resistant mechanism of Serratia mareescens was complex, and it showed multi - drug resistant. It is very important to rationally use antibiotics according to susceptibility testing results.
出处
《华西医学》
CAS
2005年第4期688-690,共3页
West China Medical Journal
关键词
粘质沙雷菌
分布
耐药性
Serratia marcescens
Distribution
Resistant analysis