血浆脑钠肽水平与心力衰竭病人心功能的关系

Relationship between Natriuerctic Peptide Level and Cardiac Function in Patients with Heart Failure.

目的研究心力衰竭病人血浆脑钠肽(BNP)水平与心力衰竭严重程度、左室功能等因素的关系。方法采用化学发光免疫分析法测定80例心力衰竭病人BNP水平,用心脏彩色多普勒超声仪测定其左室功能。结果BNP水平随着心功能纽约分级(NYHA)程度的加重而显著增加,其与左室射血分数(LVEF)呈负相关(r=-0.407,P<0.01),与LVEDD、LVMI呈正相关,相关系数分别为r=0.351(P<0.01)、r=0.369(P<0.05)。结论心力衰竭病人血浆BNP水平随着心力衰竭严重程度的增加而升高,并能较好地反映左室功能状态。

Objective To investigate the relationship between Plasma brain natriuretic peptide （BNP） and the severity of congestive heart failure and left ventricular systolic function. Methods BNP was measured by radioirnmunoassay method. Colored dopler echocardiography was performed to measure the left ventricular function. Results Plasma levels of BNP were increased in proportion to the severity of left ventricular dysfunction. Plasma levels of BNP were a negative correlation with LVEF （P 〈 0.01 ）, and a positive correlation with left ventricular end diastolic diameter （P 〈 0.01 ） and left ventricular mass index （ P 〈 0.05）. Conclusion Plasma levels of BNP were increased in proportion to the severity of left ventricular dysfunction and in contrast with the left ventricular function and structure in patients with CHF.