缬沙坦治疗慢性心力衰竭的疗效观察

Chronic Heart Failure Treated by Valsartan

目的观察缬沙坦对慢性心力衰竭病人心功能的治疗作用。方法选择慢性心力衰竭病人62例,随机分为两组,对照组使用血管紧张素转换酶抑制剂(ACEI)类药物髓袢利尿剂、洋地黄;治疗组加用缬沙坦。对治疗前后两组间临床资料进行比较。结果治疗组心功能NYHA分级好转率优于对照组(P<0.05);左室射血分数(LVEF)增加,左室舒张末内径(LVIDD)缩小,比较有统计学意义(P<0.05),6min步行试验治疗组距离明显长于对照组(P<0.05)。结论用缬沙坦治疗慢性心力衰竭明显优于常规治疗,可显著改善心力衰竭病人临床症状体征。

Objective To observe the clinical effect of Valsartan on chronic heart failure （CHF）. Methods Sixty- two patients with chronic heart failure were divided into two groups randomly. The patients （pts） in Group A were treated by ACEI, diuretic, and digitalis. The pts in Group B were treated by valsartan on the base of routine treatment. Results Cardiac function improved obviously in the Group B： LVIDD decreased, EF increased significantly. There was significant difference between Group A and Group B treated by Valsartan （ P 〈 0.05）. Conclusion Valsartan could improve the left ventricle remodeling, cardiac function and the life quality of pts with CHF obviously.