妊娠高血压综合征并发妊娠肾病综合征22例临床分析

Retrospective Analysis of 22 Cases of Pregnancy with Nephritic Syndrome

目的探讨分析妊娠肾病综合征临床特点和治疗方法。方法采用回顾分析方法,对2001年3月—2005年3月收治的22例妊娠高血压综合征(妊高征)并发妊娠肾病综合征与167例妊高征临床资料进行比较。结果妊娠肾病综合征发病孕周(27.8周)早于妊高征(31.4周,P<0.05)。妊娠肾病综合征低蛋白血症发病率(100.0%),明显高于妊高征(42.0%,P<0.01)。妊娠肾病综合征24h尿蛋白定量(7.5g/24h)明显高于妊高征(4.1g/24h,P<0.05)。妊娠肾病综合征血清清蛋白浓度(26.9g/L)明显低于重度妊高征(30.6g/L,P<0.05)。妊娠肾病综合征胆固醇浓度(9.17mmol/L)明显高于妊高征(7.4mmol/L,P<0.05)。妊娠肾病综合征新生儿出生体重(1490g)与妊高征(2640g)相比,有统计学意义(P<0.01)。结论妊娠肾病综合征发病早,病情重,严重威胁孕产妇和胎儿安全。

Objective To analyze the clinical characteristic and treatment of pregnancy with nephritic syndrome （PNS）. Methods The clinical materials were analyzed retrospectively for 22 patients （pts） with PNS and 167 pts with severe preeclampsia, Results The symptom of PNS appeared earlier than that of severe preeclampsia （27, 8 weeks gestation vs 31.4 weeks gestation, P〈 0. 05）. The hypoproteinemia rate of PNS was higher significantly than that of severe preeclampsia （ 100.0 % vs 42.0 %, P 〈0.01）. Urinary excretion of protein in a 24 - hour specimen of PNS was higher than that of severe preeclampsia （ 7.5 g/24 h vs 4.1 g/24 h, P 〈 0.05 ）. The level of serum Cholesterol of PNS was higher than that of severe preeclampsia（ 9.17 mmol/L vs 7.40 mmool/L, P 〈 0.05）. The birth weight of infants in PNS was less significantly than that of severe preeclampsia （1450 g vs 2 640 g, P 〈 0.01）. Conclusion PNS occurs early and severely. It is severe to threat the heaths of pregnancy women and their newborns.