匀相法测定LDL-C和Planella公式计算法结果的比较

Comparison of Low-density Lipoprotein Cholesterol (LDL-C) Measured by Homogeneous Assay and Calculated by Planella Formula

目的:分析匀相法测定血清低密度脂蛋白胆固醇(LDL-C)值与Planella公式(P公式)计算结果,评价甘油三酯(TG)及胆固醇(TC)对P公式计算LDL-C值的影响。方法:对1862份标本,在日立7600-020全自动生化分析仪上测TC、TG、LDL-C高密度脂蛋白胆固醇(HDL-C),同时运用P公式计算每份标本的LDL-C值,进行统计学处理。结果:⑴TG≤4.52mmol/L时P公式法与匀相测定法的相关性(r=0.909)好于TG>4.52mmol/L时(r=0.807)。⑵TG≤4.52mmol/L时,TC<6.20mmol/L组二种结果的相关性好于TC>6.20mmol/L组;而当TG>4.52mmol/L时,TC<6.20mmol/L组二种结果的差异最大(r=0.733)。结论:P公式在TG水平≤4.52mmol/L与TC≤6.20mmol/L时。在确保TC、TG、HDL-C结果准确的情况下,可以用P公式计算的LDL-C值作为参考。

Objective：To compare LDL- C result measured by homogeneous assay and the result calculated by Planella formula, and to evaluate the influence of TG and TC to LDL- C results with Planella formula＇ s method. Methods： 1862 specimens were collected and determined directly LDL- C, TG, TC and HDL-C by HITACHI 7600-020 analyzer, and LDL- C was calculated respectively by Planella formula. Resuits：（1）When TG≤4.52mmol/L , the correlation of both LDL - C values of Planella formula and Homogeneous assay（r = 0. 909） was better than in the group of when TG 〉 4.52mmol/L （ r = 0. 807） . （2）When TG≤4.52mmol/L, the correlation in the group of TC〈 6.21mmol/L was better than in the group of TC 〉 6.20 mmol/L LDL- C. The correlation was worst in the group of when TG 〉 4.52mmol/L and TC〈 6.20mmol/L （ r = 0. 733） . Conclusions： LDL - C results of PlaneUa formula was correlated with results of Homogencous assay in TG≤ 4.52mmol/L, especially when TC was also lower than 6.20mmol/L. The calculated LDL-C could be used as reference on the basis of reliable TC , TG and PIDL- C measurement.