递增负荷运动过程中ER、PR水平的变化及其与性腺类固醇的关系

Changes of ER and PR level and relationship between receptors and sex hormones during progressing increasing training load

低性腺类固醇水平是AMI的重要特征之一。为了探讨低性激素环境下ER(雌激素受体)、PR(孕激素受体)的变化特点及激素与受体间的相互影响作用关系,并探讨其在运动性月经失调中的作用机制,本研究对递增负荷运动过程中及4个恢复期后,大鼠子宫和卵巢ER、PR及血清E2、P水平的变化进行了连续监测。结果显示,血清E2、P随运动负荷量的加大而逐渐降低,组织ER、PR水平随运动负荷量的加大呈渐进性升高。受体水平在停训后的恢复期内随着E2、P水平的回升,逐渐回落。结果表明,运动中受体水平的变化可能为非激素依赖性升高,这种升高或许是机体对长期运动训练造成的低性激素环境的一种适应性反应,可能是AMI病理机制过程的重要一环。恢复期受体水平的恢复与E2水平的升高具有直接关系。

Lower female steroids level is one of important characteristics. In order to investigate the change feature of ER and PR during lower sex hormones and the relationship between receptor and hormone, the mechanism of receptor and hormone changes in AMI, this study was monitoring to the serum E2, P, ER and PR of uterus and ovary during progressing increasing training load and 4 recovering cycles. The results showed that E2 and P level was significantly decreased , ER and PR level was markedly elevated with training load increasing. Receptor level gradually recovered with sex hormone reversal during recovery phase. The results indicated that higher receptor level may be non-dependence on sex steroids, but the adaptable response to lower sex hormone circumstance, and may be an important cycle of athletic menstrual irregularity pathetic process. Receptor level reversal was relation to the E2 level re-increasing during recovery phase.