通络益智散对血管性痴呆大鼠脑组织HSP70表达的影响

The Effect of Tongluoyizhi Powder on Expression of Heat Shock Protein 70 in Mice with Vascular Dementia

目的：通过动物实验探讨通络益智散对 VD 大鼠脑组织 HSP70表达的影响。方法：以13只 Wistar 大 鼠为一组，随机共设5组：空白组、模型组、通络益智散低剂量组、通络益智散高剂量组、尼莫地平组。除空白组外， 其余各组采用腹腔注射硝普纳及反复夹闭双侧颈动脉的方法，制造血管性痴呆模型。3周后，在脑组织观察 HSP70 的表达。结果：模型组及给药各组 VD 大鼠脑内 HSP70的表达均明显高于正常组(P＜0． 01) 。结论：通络益智散 能够增强 HSP70的表达，增加脑细胞对缺氧的耐受性，抵抗进一步致死性损伤。

Objective ：To study the effect of Tongluoyizhi powder on expressing of Heat Shock Protein 70 in mice with vascular dementia. Methods ：The animals were randomly divided into 5 equal groups（ n = 13） ：The normal control group, and model group, and Tongluoyizhi powder（high and low dosage）, and Nimodiping group. The model of rats were established through two sides of CCA were clamped repeatedly and sodium nitroprusside was administered by i.p. 3 weeks later, observe the expression of Heat Shock Protein 70 in hippocampus. Results ： The expression of HSP 70 in nomal group was significantly lower thtan other groups（P 〈 0.01）. Conclusion ： Tongluovizhi powder can enhance the expreasion of HSP70.