三七茜草复方对置铜宫内避孕器家兔血液流变学指标的影响

Effects of Sanqi Qiancao Recipe on hemorheological parameters of rabbits with copper intrauterine device

目的:探讨三七茜草复方(Sanqi Qiancao Recipe,SQR)治疗兔置铜宫内避孕器所致子宫异常出血的作用机制。方法:56只家兔,随机分成SQR大、中、小剂量组,吲哚美辛对照组,模型组,假手术组(手术后不放置宫内避孕器)及空白对照组(不造模),每组8只,其中前5组建立家兔置铜宫内避孕器模型。SQR大、中、小剂量组及吲哚美辛对照组分别予以SQR大、中、小剂量及吲哚美辛灌胃1周。模型组、假手术组及空白对照组则予以蒸馏水灌胃1周。治疗后测定血细胞比容,全血黏度低、中、高切变率,血浆比黏度及血沉。结果:置铜宫内避孕器家兔血细胞比容,全血黏度低、中、高切变率及血浆比黏度较空白对照组均有明显升高,差异有统计学意义(P<0.01)。SQR治疗组家兔血细胞比容,全血黏度低、中、高切变率及血浆比黏度均较模型组低,差异有统计学意义(P<0.05或P<0.01)。结论:改善血液流变性可能是SQR防治宫环出血病的机制之一。

Objective： To explore the mechanism of Sanqi Qiancao Recipe （SQR） in treating metrorrhagia caused by copper intrauterine device （IUD） in rabbits and to provide experimental evidence for preventing and treating this disease. Methods： Fifty-six rabbits were randomly divided into seven groups, which were normal control group, sham-operation group, untreated group, indomethacin-treated group, low-dose SQR- treated group, medium-dose SQR-treated group and high-dose SQR-treated group. Copper IUD insertion was operated in rabbits of the last five groups. Rabbits in the last four groups were treated orally with indometha- cin and low-, medium- and high-dose SQR respectively for a week. Rabbits in the untreated group, normal control group and sham-operation group were given distilled water orally. Hemotocrit, blood viscosity at low, medium and high shear rate, plasma viscosity and blood sedimentation were examined after treatment. Results： The hemotocrit, blood viscosity at low, medium and high shear rate and plasma viscosity were high- er in the untreated group than those in the normal control group with significant differences （ P〈0.01 ） while those indexes in low-, medium- and high-dose SQR-treated groups were significantly lower than those in the untreat- ed group （P〈0.05 or P〈0.01 ）. Conclusion： SQR can lead to a decrease in blood viscosity and improve the blood flow, which may be one of the mechanisms of SQR in treating metrorrhagia after copper IUD insertion.