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环境中内分泌干扰物的作用机制 被引量：17

The Action Mechanism of Environmental Endocrine Disruptors
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摘要 随着对环境激素问题的关注,对环境中残留化合物的荷尔蒙效应研究已成为一个关系到人类今后生存与繁衍的热点问题。该文从内源性激素的生理学机制出发对当前环境内分泌干扰物的机制研究作了较系统综述。内容不仅阐述了已知的受体介导影响途径,还讨论了环境激素通过破坏内源性激素及其受体的生成和代谢而产生内分泌干扰作用的非受体介导途径,以及污染物对神经系统、免疫系统和内分泌系统的综合效应。同时,该文提出了以环境激素作用机制为基础,为进一步开发和发展新的生物筛选方法提供技术路线。 Research on effects of environmental endocrine disrupting chemicals （EDCs） is an important field in environmental science. The research progress on mechanism of EDCs in environment was present in this paper. Not only the action mechanism of EDCs mediated via receptor was expatiated, but also the interference influencing the synthesis and metabolism of endogenous hormone and the effects of EDCs on neural and immune system were discussed in this paper. This paper will conduce to the further studies on the mechanism of EDCs and the development of screening method for new EDCs.
作者 伍吉云 万祎 胡建英
机构地区 井冈山学院生理教研室 北京大学环境学院
出处 《环境与健康杂志》 CAS CSCD 北大核心 2005年第6期494-497,共4页 Journal of Environment and Health
基金 国家自然科学基金资助项目(20377002)
关键词 激素 内分泌系统 雌激素类 Hormone Endocrine system Estrogens
分类号 R994.6 [医药卫生—毒理学]
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参考文献24

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二级参考文献16

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共引文献6

同被引文献389

引证文献17

二级引证文献99

环境与健康杂志
2005年 第6期

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