老年冠心病患者血清sICAM-1、CRP、sVAP-1的异常表达及临床意义

Abormal expressions of sICAM-1,sVAP-1 and CRP in the elderly patients with coronary heart disease and their clinical significances

目的:探讨可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管黏附蛋白-1(sVAP-1)、C反应蛋白(CRP)等相关指标在老年急性心肌梗死患者及稳定性心绞痛患者体内表达及其临床意义。方法:通过ELISA法分别检测老年急性心肌梗死患者、稳定性心绞痛患者及健康老年人体内sICAM-1、sVAP-1、CRP水平并对各指标作组间比较以分析三组之间差异。结果:三指标以急性心肌梗死患者体内水平为最高,与稳定性心绞痛患者及健康老年人之间的差异有显著性(P<0.01);心绞痛组三指标较正常对照组差异有显著性(P<0.01)。结论:稳定性心绞痛患者、心肌梗死患者血清sVAP-1、sICAM-1、CRP异常表达,其表达水平与疾病严重程度有关,sVAP-1、sICAM-1、CRP参与了心血管疾病的形成与发展。

Objective：To investigate and compare the expressions of soluble interceUular adhesion molecule-1 （sICAM-1）,soluble vascular adhesion protein-1 （sVAP-1） and C-reactive protein （CRP） in the elderly patients with stable angina pectoris and acute myocardial infarction and their clinical significances.Methods：The levels of sICAM-1,sVAP-1 and CRY in acute myocardial infarction group, stable angina pectorics group and normal control group were respectively measured by ELISA,and compared among them.Results：The levels of sICAM-1,sVAP-1 and CRY were highest in the acute myocardical infarction group compared with those in the stable angina pectofis group and normal control group,with significant difference （P〈0.01）,and lowest in the control group.The difference between stable angina pectoris group and control group was significant （P〈0.01）.Conclusion：There were abnormal expressions of sICAM-1,sVAP-1 and CRY in the eMerly patients with stable angina pectoris or acute myocardial infarction,their levels of expression were associated with the serious degree of this disease.sICAM-1,sVAP-1 and CRY participated in the formation and development of cardiovascular diseases.