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血管生长抑制因子Kringle5的发酵条件研究

Optimization of Fermentation Conditions for Expression of Angiogenesis Inhibitor Kringle 5
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摘要 确定了适合重组工程菌生长和血管生长抑制因子Kringle5表达的培养基,并采用正交试验优化了重组工程菌的发酵条件。20L发酵罐中Kringle5蛋白的最终表达量为0.59g/L。 The optimum fermentation conditions for the growth of the recombinant E.coli strain and the expression of angiogenesis inhibitor Kringle 5 were investigated using orthogonal design. The final productivity of Kringle 5 was 0.59g/L in 20L fermenter.
作者 党红艳 边六交
机构地区 西北大学西部资源生物与现代生物技术教育部重点实验室
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2005年第11期674-677,共4页 Chinese Journal of Pharmaceuticals
基金 陕西省科技攻关项目(2003K10-G58)
关键词 血管生长抑制因子 发酵 基因表达 正交试验 angiogenesis inhibitor fermentation gene expression orthogonal experiment
分类号 TQ925 [轻工技术与工程—发酵工程]
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参考文献12

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中国医药工业杂志
2005年 第11期

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