低分子肝素-壳聚糖-羧甲纤维素钠微囊的制备及释药性能

Preparation of Low Molecular Weight Heparin-Chitosan-Sodium Carboxymethyl Cellulose Microcapsules and Its Drug-Release Performances

采用乳化分散交联法,制备了低分子肝素-壳聚糖-羧甲纤维素钠微囊,考察了不同处方工艺对微囊释药性能的影响。按最佳工艺制得的微囊形态圆整,粒径2～7μm,包封率和载药量分别为92.3%和6.47%,微囊释药具pH依赖性。兔体内释药实验的结果表明,低分子肝素微囊较注射液缓释效果明显。

Low molecular weight heparin-chitosan-sodium carboxymethyl cellulose microcapsules were prepared by means of emulsion-dispersion cross-linking method. The influence factors of the different preparations on the drug-release performances of the microcapsules were investigated. The results showed that the microcapsules prepared by optimized conditions were smooth spherical with 2-7μm diameter. Encapsulation efficiency and drug loading were 92.3% and 6.47%, respectively. The release rate of the microcapsules was dependent on pH value of the media. The result tested in rabbits indicated that the microcapsules had a significant sustained release effect compared with the injection.