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载脂蛋白AⅤ基因对血脂和心血管疾病的影响 被引量：2

Influence of Apolipoprotein A5 Gene on Plasma Lipoprotein Level and Cardiovascular Disease
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摘要 随着科学研究的进展,有关载脂蛋白AⅤ(apoAⅤ)基因的功能发现得越来越多。目前发现apoAⅤ基因单核苷酸多态性对血脂有影响,尤其是对三酰甘油有影响。另外还发现它同心血管疾病有联系,但研究结果尚不一致。 With the development of science research,people find more and more function about apoA5 gene. The main finding is that apoA5 single-nucleotide polymorphisms can affect plasma lipoprotein level,especially triglyceride. What＇s more,people also find the association with cardiovascular disease. But the findings are disagree.
作者 常静 陈焕芹
机构地区 山东大学齐鲁医院干部保健科
出处 《心血管病学进展》 CAS 2005年第6期617-619,共3页 Advances in Cardiovascular Diseases
关键词 apoAⅤ基因 单核苷酸多态性 血脂 心血管疾病 ApoA V Gene Single-nucleotide polymorphisms Plasma lipoprotein level Cardiovascular disease
分类号 R54 [医药卫生—心血管疾病]
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参考文献18

  • 1Pennacchio LA,Olivier M,Hubacek JA,et al.An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing[J].Science,2001,294(5540): 169-173.
  • 2Prieur X,Coste H,Rodriguez JC.The human apolipoprotein AⅤ gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element[J].J Biol Chem,2003,278(28): 25468-25480.
  • 3Wung SF,Aouizerat BE.Gender and ethnic differences in a case-control study of dyslipidemia: using the apolipoprotein AⅤ gene as an example in cardiovascular genetics[J].Res Theory Nurs Pract,2003,17(4):281-299.
  • 4Nabika T,Nasreen S,Kobayashi S,et al.The genetic effect of the apolipoprotein AⅤ gene on the serum triglyceride level in Japanese[J].Atherosclerosis,2002,165(2): 201-204.
  • 5刘合焜,王春婷,张思仲,肖翠英,李雪飞,张克兰,张立,苏智广,马用信,周斌,郑克勤,李贵星.APOA5基因单核苷酸多态性与冠心病相关性研究[J].中华医学遗传学杂志,2004,21(4):335-338. 被引量：21
  • 6Baum L,Tomlinson B,Thomas GN.ApoA5-1131T> C polymorphism is associated with triglyceride levels in Chinese men[J].Clin Genet,2003,63(5):377-379.
  • 7Lai CQ,Demissie S,Cupples LA,et al.Influence of the apoA5 locus on plasma triglyceride,lipoprotein subclasses,and CVD risk in the Framingham Heart Study[J].J Lipid Res,2004,45(11):2096-2105.
  • 8Jang Y,Kim JY,Kim OY,et al.The -1131T-> C polymorphism in the apolipoprotein A5 gene is associated with postprandial hypertriacylglycerolemia;elevated small,dense LDL concentrations;and oxidative stress in nonobese Korean men[J].Am J Clin Nutr,2004,80(4):832-840.
  • 9Hubacek JA,Skodova Z,Adamkova V,et al.The influence of apoAⅤ polymorphisms (T-1131》C and S19》W) on plasma triglyceride levels and risk of myocardial infarction[J].Clin Genet,2004,65(2):126-130.
  • 10Talmud PJ,Martin S,Taskinen MR,et al.ApoA5 gene variants,lipoprotein particle distribution,and progression of coronary heart disease: results from the LOCAT study[J].J Lipid Res,2004,45(4):750-756.

二级参考文献11

  • 1Nabika T, Nasreen S, Kobayash S, et al. The genetic effect of the apoprotein AⅤ gene on the serum triglyceride level in Japanese. Atherosclerosis,2002,165:201-204.
  • 2Baum L, Tomlinson B, Thomas GN. APOA5-1131T>C polymorphism is associated with triglyceride levels in Chinese men. Clin Genet, 2003,63:377-379.
  • 3Endo K, Yanagi H, Araki J, et al. Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren. Hum Genet,2002,111:570-572.
  • 4Martin S, Nicaud V, Humphries SE , et al. Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges. Biochim Biophys Acta,2003,1637:217-225.
  • 5Pennacchio LA, Olivier M, Hubacek JA, et al. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science,2001,294:169-173.
  • 6van der Vliet HN, Sammels MG,Leegwater AC, et al. Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration. J Biol Chem, 2001,276:44512-44520.
  • 7Pennacchio LA, Rubin EM. Comparative genomic tools and databases: providing insights into the human genome. J Clin Invest, 2003,111:1099-1106.
  • 8Aouizerat BE,Kulkarni M, Heilbron D, et al. Genetic analysis of a polymorphism in the human apo A-V gene: effect on plasma lipids. J Lipid Res,2003,44:1167-73.
  • 9Ribalta J, Figuera L, Fernandez-Ballart J, et al. Newly identified apolipoprotein AⅤ gene predisposes to high plasma triglycerides in familial combined hyperlipidemia. Clin Chem,2002,48:1597-1600.
  • 10Pennacchio LA, Olivier M, Hubacek JA, et al. Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. Hum Mol Genet,2002,11:3031-3038.

共引文献20

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心血管病学进展
2005年 第6期

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