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甲状腺激素调节小脑发育的机制 被引量：2

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摘要 甲状腺激素对哺乳动物小脑的正常发育是非常重要的,它促进小脑的发育成熟。具体表现在促进颗粒细胞的增生和准确迁移、减少颗粒细胞的凋亡、促进浦肯野细胞的分化以及颗粒细胞和浦肯野细胞之间突触的正常形成。围生期甲状腺功能减退可能导致上述发育过程异常,造成严重的小脑结构和功能的改变。鉴于妊娠早期母体的甲状腺激素就可通过胎盘进入胎儿体内发挥作用,因此妊娠妇女即使有轻微的甲状腺功能减退也应及时补充甲状腺素制剂。
作者 张洪梅 苏青
机构地区 上海交通大学医学院附属新华医院
出处 《国外医学（内分泌学分册）》 2005年第6期367-370,共4页 Foreign Medical Sciences(Section of Endocrinology)
基金 国家自然科学基金资助项目(30200127)
关键词 甲状腺激素 小脑 生长发育 细胞迁移 细胞凋亡 甲状腺激素 小脑发育 激素调节 甲状腺功能减退 浦肯野细胞 颗粒细胞 甲状腺素制剂 正常发育 哺乳动物
分类号 R338 [医药卫生—人体生理学]
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参考文献20

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同被引文献20

  • 1S. Dasgupta,J. A. Adams,E. L. Hogan.Maternal Alcohol Consumption Increases Sphingosine Levels in the Brains of Progeny Mice[J]. Neurochemical Research . 2007 (12)
  • 2Pasquini JM,Adamo AM.Thyriod hormones and the centralnervous system. Developmental Neuroscience . 1994
  • 3Nathaniel EJ,Hassard T,Burton L,et al.Effect of exoge-nous thyroxine on the development of the Purkinje cell infetal alcohol effects in the rat. Experimental and Molecular Pathology . 1999
  • 4Paxinos G,Watson C.The rat brain in stereotaxic coordi-nates. . 2006
  • 5Hao W,Chen H,Su Z.China:alcohol today. Addiction . 2005
  • 6Jin F,Chung YY,Park SK.Effect of maternal thyroxinetreatment on the offspring’’s brain development with fetalalcohol effects in the rats. Korean J Pediatr . 2006
  • 7Ramadoss J,,Lunde ER,Pi觡a KB,et al.All threetrimester binge alcohol exposure causes fetal cerebellarpurkinje cell loss in the presence of maternal hypercapnea,iagonal,and normoxemia:ovine modelAlcoholism Clinical and Experimental Research,2007.
  • 8Lindholm D,Hamner S,Zirrgiebel U.Neurotrophins andcerebellar development. Perspectives on Developmental Neurobiology . 1997
  • 9Camboni D,Roskoden T,Schwegler H.Effect of earlythyroxine treatment on brain-derived neurotrphic factormRNA expression and protein amount in the rat medialseptum/iagonal band of Broca. Neuroscience Letters . 2003
  • 10J Hankin.Fetal alcohol syndrome prevention research. Alcohol Research & Health . 2002

引证文献2

二级引证文献3

国外医学（内分泌学分册）
2005年 第6期

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