狭瓣鹰爪花的生物碱成分研究

Studies on the alkaloids from stem of Artabotrys hainanensis

目的:研究海南狭瓣鹰爪花茎的生物碱成分。方法:生药用70%乙醇提取,提取物酸水溶解,酸水液氨水碱化后氯仿萃取,氯仿部位用硅胶柱色谱等色谱方法分离纯化,NMR等波谱法进行结构鉴定。结果:分离得到了8个生物碱类化合物,结构鉴定为spinosine(1),3-hydroxynornuciferine(2),juzirine(3),artabotrine(4),liridine(5),assim-ilobine(6),isococlaurine(7),-Ndemethylarmepavine(8)。结论:上述化合物均为首次从该植物中分得,化合物1,3,7,8为首次从该属植物分得。

Objective： To investigate the alkaloids from the stem of Artabotrys hainanensis. Method： Compounds in plant extracts were separated by silica gel and sephadex LH-20 colmnn chromatography. Chemical structures were elucidated by chemical and spectral analyses including UV, ^1H-NMR, ^13C-NMR, ESIMS and ESI-MS-MS. Result： Eight alkaloids were isolated and identified as spinosine （1）, 3-hydroxynomuciferine （2）, juzirine （3）, artabotrine （4）, liridine （5）, assimilobine （6）, isococlaurine （7）, N-emethylannepavine （8）. Conclusion： All alkaloids were isolated from this plant for the first time and compounds 1, 3, 7 and 8 were isolated from genus Artabotrys for the first time.