麻黄汤对小鼠的发汗作用

The Effect of Mahuangtang on Diaphoretic Function in Mice

目的观察麻黄汤对小鼠的发汗作用,探讨方中诸药君臣佐使的地位,阐明麻黄汤的配伍规律。方法采用组织形态学方法,以小鼠腋窝部皮肤汗腺导管的内径为发汗量的评价指标,观察麻黄汤给药后30min对小鼠的发汗作用。结果麻黄汤组、麻黄加桂枝组、麻黄组、桂枝组、杏仁组、甘草组、空白对照组小鼠腋窝部皮肤汗腺导管的内径分别为(3.298±0.122)μm,(3.778±0.183)μm,(2.965±0.153)μm,(0.763±0.104)μm,(0.515±0.104)μm,(0.523±0.098)μm,(0.508±0.111)μm。其中麻黄加桂枝组发汗作用最强,麻黄、桂枝具有发汗作用,杏仁、甘草无发汗作用。结论麻黄、桂枝、杏仁、甘草在麻黄汤中分别起到君臣佐使的作用,深刻体现了组方规律。

Objective ：To study the influence of Mahuangtang（MHT） on diaphoretic function in mice, to discuss their status, such as principle, assistant, adjuvant and dispather-the four regular parts of a priscription, of the ingredients in MHT, and to illuminate compatible theories of MHT. Methods ： Duct diameter of axillary sweat gland was taken as an index to estimate sweating quantity, the diaphoretic function of MHT observed at thirty minute after administration. Results ： The duct diameter of axillary sweat gland of MHT group, Mahuang ＋ Guizhi group, Mahuang group, Guizhi group, Xingren group, Gancao Group was（3. 298 ± 0.122）μm, （3. 778 ± 0. 183）μm, （2. 965 ± 0. 153）μm, （0. 763 ± 0. 104）μm, （0. 515 ± 0. 104） μm, （0. 523 ± 0. 098）μm, （0.508 ± 0.111 ）μm, respectively. Mahuang ＋ Guizhi compatible group was the strongest in seven groups. Mahuang and Guizhi had the diaphoretic function in mice, but Xingren and Gancao hadn＇ t. Conclusions ： Mahuang, Guizhi, Xingren, and Gancao played a role of principle drug, assistant drug, adjuvant drug and dispather drug in the docoction separately. It embodied the compatible theories of the priscription thoroughly.