实验性自身免疫性视网膜葡萄膜炎的视网膜脂类过氧化产物测定

Astudyonchangesoflevelsofproductsoflipidperoxidationinretinaofratwithexperimentalau┐toimmuneveoretinits

目的探讨实验性自身免疫性视网膜葡萄膜炎（ｅｘｐｅｒｉｍｅｎｔａｌａｕｔｏｉｍｍｕｎｅｕｖｅｏｒｅｔｉｎｉｔｉｓ，ＥＡＵ）的组织损伤机理。方法利用视网膜Ｓ抗原诱发大鼠ＥＡＵ模型。在不同时间点，测定了视网膜脂类过氧化产物（共轭二烯、丙二醛、荧光色脂质及脂质氢过氧化物）的水平。结果在ＥＡＵ的病变过程中，脂类过氧化产物的水平均增高。结论自由基介导的脂类过氧化可能是造成ＥＡＵ视网膜病理损害的因素之一。

ObjectiveTounderstandthemechanismsoftheretinaltissuedestructionofratwithex-perimentalautoimmuneuveoretinitis(EAU)inucedbyrabbitretinalsolubleantigen.Methodthelevelsofthefolowingproductsoflipidperoxidationweredeterminedatdiferenttimes:conjugateddienes,malondialdehyde,fluorochromelipidandlipidhydrogenperoxide.ResultIntheprocessofEAU,thelevelsofproductsoflipidperoxidationintheretinawereincreasedgradualyinvariousdegrees.Conclu┐sionItissuggestedthatthedamagefromlipidperoxidationmediatedbyfreeradicalsoftheretinabeoneofthefactorswhichinducestheretinaldestructioninEAU.