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21世纪重要耐药威胁——超广谱β-内酰胺酶的特点和检测

Characteristic and examination of extended spectrum β-lactamases, important intimidation of tolerate in the 21th century
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摘要 细菌耐药性已成为全球性问题,其中革兰氏阴性菌产生超广谱β-内酰胺酶(ESBLs)的问题得到了广泛关注[1].超广谱β-内酰胺酶是由细菌质粒介导的、能水解广谱β-内酰胺类抗生素的一种酶.近年来β-内酰胺类抗生素的广泛应用及不合理使用,使耐药菌株迅速增加.
作者 李智慧
机构地区 天津出入境检验检疫局
出处 《口岸卫生控制》 2005年第5期27-30,共4页 Port Health Control
关键词 超广谱Β-内酰胺酶 细菌耐药性 21世纪 广谱β-内酰胺类抗生素 检测 威胁 革兰氏阴性菌 全球性问题 质粒介导
分类号 R978.11 [医药卫生—药品] R978.1 [医药卫生—药品]
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参考文献21

  • 1Bradford PA.Extended-spectrum β-lactamases in the 21st century:characterization,epidemionlogy,and detection of this important resistancethreat[J],2001(04).
  • 2侯天文,张健,王宪灵,陈兴.PER型超广谱β-内酰胺酶研究进展[J].国外医学（流行病学．传染病学分册）,2003,30(1):37-38. 被引量：3
  • 3Chang FY.Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.[J],2001(09).
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二级参考文献54

  • 1Bradford PA. Extended-spectrum β-lactamases in the 21st century : characterization, epidemionlogy, and detection of this important resistance threat. Clin Micro Rev,2001,14(4): 933.
  • 2Christophe DE, Champs , Claire M, et ad: New TEM variant (TEM-92) produced by proteus mirabilis and providencia stuartii isolates. Antimicrob Agents Chemother ,2001; 45(4) : 1278.
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  • 5Decousser JW, Poirel L, Nordamann P.Characterization of a chromosomal encoded extended spectrum class A β-lactamase from kluyvera cryocrescens. Antimicrob Agents Chemother, 2001,45(12): 3595.
  • 6Winokur PL,Canton R ,Casellas JM ,et al. Variations in the prevalence of stains expressing an extended-spectrumβ-lactamase phenotype and characterization of isolates from Europe, the Americas, and the western pacific region. Clin Infect Dis, 2001, 32(Supply 2): S94.
  • 7Champs CD,Sirot D,Chanal C,et al. A 1998 survey of extended-spectrum β-lactamases in　Enterobacteriaceae in France . Antimicrob Agents Chemother,2000,44(11): 3177.
  • 8Spanu T, Luzzaro F. Occurrence of extended-spectrum β-lactamases in members of the family Enterobacteriaceae in Italy: implications for resistance to β-lactamas and other antimicrobial drugs. Antimicrob Agents Chemother, 2003, 46(1):196.
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  • 10Fred C, Tenover T. Development and spread of bacterial resistance to antimicrobial agents: an overview. Clin Infect Dis ,2001, 33 (Supply 3): 108.

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口岸卫生控制
2005年 第5期

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