摘要
细胞间黏附分子-1(ICAM-1)和血管细胞黏附分子-1(VCAM-1)在脑缺血损伤炎症过程中起着重要作用。脑缺血后ICAM-1和VCAM-1表达增加;ICAM-1、VCAM-1介导循环中的白细胞与内皮细胞黏附,进而浸润到血管外脑实质,导致缺血后炎症;抑制ICAM-1、VCAM-1表达及作用可减轻脑缺血损伤。
1ntercellular adhesion molecules 1 （ ICAM- 1 ） and vascular cell adhesion molecule 1 （VCAM-1） play important roles in the inflammatory process of cerebral ischemic injury. The expression of ICAM-1 and VCAM-1 increases following cerebral ischemia; ICAM-1 and VCAM-1 promote ischemic inflammation throughmediating leukocytes adhesion to the endothelial cells and eventually migration into brain tissue; the inhibition of the overexpression and effect of ICAM-1 and VCAM-1 can reduce cerebral ischemic injury.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2005年第11期1281-1285,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No30271498)
浙江省教育厅科研计划项目(No20020984)
关键词
脑缺血
细胞间黏附分子-1
血管细胞黏附分子-1
brain ischemia
intercellular adhesionmolecules-1
vascular cell adhesion molecule-1
